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New
to the HCM Gentest of the medical small animal hospital of the Ludwig
Maximilians university in Munich was accomplished a study to the two
gene tests on HCM, available in Germany, with Maine Coons. The result
shows that the gene test does not bring anything. The study resulted in
that Maine Coons with HCM are just as frequently positively tested in
the gene test, as Maine Coons without HCM.
Therefore the investment is not worthwhile itself into a gene test
simply. In the following one we printed the result of the study, which
was presented on the last weekend in the context of a lecture on a
specialized congress for the animal medical profession in pouring.
Genetic association of the A31P- and A74T-Polymorphismen with the
felinen hypertrophen Kardiomyopathie with the Maine Coon C. Schinner,
K. Weber, K. Hartmann, G. Wess, Abteilung for Kardiologie of
the medical small animal hospital of the Ludwig Maximilians university
Munich introduction: The hypertrophe Kardiomyopathie (HCM) is the most
frequent feline heart illness with autosomal dominantem hereditary
course and varying Penetranz. The A31P- and A74T-Polymorphismen (SNPs)
in the kardialen Myosin being thing protein C3-Gen (MYBPC3) are regarded
at present as causal mutations with Maine Coon cats. In practice
ultrasonic diagnoses deviate frequently from the Genotyp. From
zuechterischer as well as veterinary side is unclear, how with
heart-healthy Genotyp positive cats will proceed are. A goal of the
study were therefore the evaluation of the clinical association of both
SNPs as well as the evaluation of the clinical validity of gene tests
already marketed. Material and methods: 83 Maine Coon cats and 68 cats
of different races entered study. Female animals had to be older as 36
months, male older than 24 months.
The phenotype "heart-healthy" or "HCM" had to be
clear to assign. The Phaenotypisierung took place by means of heart
ultrasonic, the Genotypisierung by means of Taqman® Genotyping Assays.
Results: 21,13% of the heart-healthy animals were positive in the gene
test for the A31P- and 32.84% for the A74T-SNP. 75% of the HCM group
carried the healthy allele concerning the A31P- and 50% concerning the
A74T-SNPs. The allele frequencies did not differ between the groups of
phenotypes significantly. On the basis the available study population no
reference existed that gene tests already marketed possess a
praediktiven value. A computer-assisted protein analysis arranged
the effect of the SNPs on the protein as benigne. The A31PPolymorphismus
is specific for Maine Coons, while the A74T-Polymorphismus occurs also
at other cat races. Conclusions: With the examined patient number no
association was found between the HCM and the examined Polymorphismen.
The gold standard for the breed selection exists further in the annual
echokardiographischen investigation.
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Health/Terveys
